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Please follow these links to our recent event sponsors:

2023 in person conference 2023: Link

2022 webinar sponsors: Link

2021 webinar sponsors: Link

SAVE THE DATES:

 

The AIT virtual webinar sessions continue into 2023 (1 hour WebEx session per talk, details are below) and the in-person 3 day conference is confirmed for spring 2023 (May 3rd, 4th and 5th in Gothenburg, Sweden, 40 minute presentation slot per speaker). 

If you have a poster that is related to inhalation toxicology and you would like it on our website and/or exhibited at the in-person conference 2023 then please let the AIT know.

Exhibitors are welcome at the in-person conference in the spring of 2023 (please contact the AIT for booking details - 10 exhibitors maximum on a first come first served basis - payment secures place; 6 places are booked).

Sponsors for the in-person conference 2023 are very welcome. Please contact the AIT for the remaining sponsorship opportunities (aitoxicology@gmail.com). 

AIT Bursary Opportunity for Early Career Inhalation Toxicologists – 2023.
 

There is one bursary available of £500 to help towards the cost of travel and registration to attend the AIT spring conference 2023. In addition, if the successful applicant is not already a member of the AIT, they will also receive 3 years free membership of the AIT to enable them to access previous conference documents and webinar recordings held in the members area of the AIT website.  

Applications are welcome at any time from interested members and non-members of the AIT. The awarding of funding will be at the discretion of the AIT Committee.

Priority will be given to individuals working within an “early career” environment, for example, MSc/PhD students, researchers studying/working within a relevant scientific field, or technicians at a recognised institution working towards a professional qualification or gaining more experience within the field of inhalation toxicology.

All applications must be made by email to the AIT at aitoxicology@gmail.com.

Applications will be assessed by the AIT committee on merit. Priority may be given to candidates who have submitted poster abstracts to the meeting.

Criteria for application:

  1. The applicant must submit a brief description of the relevance of the meeting to their training or career needs and provide the following information:

  2. A brief CV.

  3. A letter of recommendation from a supervisor or senior colleague (in lieu of recommendation from an AIT member, if unavailable).

  4. Details of alternative funding that they will receive for the meeting (the bursary will be paid following completion of the conference).

  5. Up to 3 suggestions for future educational activities/topics that would be helpful to their training.

  6. If applicable, a poster abstract.

Following the meeting and prior to receipt of the bursary funds the successful applicants must submit:

  1. A short article (approximately 500 words) describing their own research, a brief overview of the meeting, or a description of how the meeting has contributed to their training/professional knowledge (this may appear in the members-only section of the AIT website).

  2. An expense claim including receipts for expenses incurred in relation to the meeting (travel/registration).

By applying for the bursary, all applicants consent to their details being added to the AIT mailing list and will automatically receive information on other events when it becomes available.  Details will not be passed on to any other organisation without written permission.

The webinar presentation details for 2023 are below followed by the in-person conference 2023 details:

AIT Free of Charge Webinar Sessions 2023

Please register your interest in attending each session by emailing the webinar organiser Kay Rush at aitoxicology@gmail.com. Links to join each session will be sent to people that are registered (please only register if you are certain to join as spaces are limited to 150 people per presentation).

Sponsorship:

The AIT thanks our sponsors for assisting us in hosting these free of charge webinar sessions:

The British Toxicology Society (BTS) has sponsored all the webinar sessions. https://www.thebts.org/


Cerulean sponsored one session held in 2022. https://www.cerulean.com/

InTox Products sponsored one session held in 2022. https://intoxproducts.com/

VJO Canada Inc. sponsored one session held in 2022. www.vjocanada.com 

 


 

Other sponsors are very welcome. Please contact the AIT at aitoxicology@gmail.com for details.

WEBINAR SESSIONS 2023

1. Diane Stannard (LabCorp):) – This webinar has been rescheduled to Wednesday 22nd February 2023 at 14:00 to 15:00 GMT (09:00 to 10:00 EST). Sponsored by the British Toxicology Society.

Juvenile toxicology talk.

Details to follow.

2. Tobias Stoger (Helmholtz, Germany): – Monday 27th February 2023 at 15:00 to 16:00 GMT (10:00 to 11:00 EST). Sponsored by the British Toxicology Society (BTS).

Lung single cell transcriptomics to guide the development for AOP anchored-cell based assays in response to nanoparticle exposure.

Inhaled nanoparticles (NP) can cause acute and chronic inflammation. Here we seek to identify NP-specific cellular perturbation pathways and the underlying key cell types to inform adverse outcome pathway (AOP) anchored in vitro studies, by single cell transcriptomics. We exposed mice intratracheally to carbon black (CNP), tangled double-walled (DWCNT) and rigid, multi-walled carbon nanotubes (MWCNT). All lungs underwent single-cell RNA sequencing (scRNA-seq), histology and BAL analysis.

At the chosen doses all NPs caused comparable airspace neutrophilia at 12h, which increased until d6 for the CNTs but remained elevated until d28 only for MWCNT, indicating the key event (KE) acute and chronic inflammation. Comparing scRNA-seq and BAL cytokine levels at 12h, NPs specifically differentiated the fate of inflammation. In agreement with airspace neutrophilia, CNP uniquely triggered GM-CSF and CXCL1 protein release, with Csf2 and Cxcl1 mRNAs being expressed mainly in alveolar epithelial cells. DWCNT caused CCL2, -3 and -4 release involving interstitial macrophages and monocytes, associated with high BAL macrophage numbers at d6 in turn. MWCNT in contrast caused an ample BAL cytokine increase involving different cell types and specifically caused a Th2 cytokine response (CCL11, IL10), a crucial KE of fibrosis AOPs. Cell communication analysis uncovered an early (12h) distinct signaling centered around alveolar macrophages only for DWCNT, and between epithelial cells, adjacent fibroblasts and monocyte derived phagocytes for CNPs, whereas MWCNT triggered a broad network including epithelial cells, fibroblasts, macrophages, dendritic cells and endothelial cells.

Our study uncovers early NP-specific cell perturbations and identified first specific cellular response pattern which can guide AOP predictive cell-based testing strategies. Further analysis of the cellular dynamics shall enhance our understanding of NP specific cell circuits and related pathologies.

3. Otmar Schmid (Helmholtz, Germany) Monday 6th February 2023 at 15:00 to 16:00 GMT (10:00 to 11:00 EST). Sponsored by the British Toxicology Society (BTS).

A New Look at Aerosol Deposition, Dosimetry and Biokinetics of Nanoparticles in the Lung.

 

Background: Understanding the dynamic process of spatially resolved particle deposition and subsequent particokinetics in the lung is of utmost importance for therapeutic and toxicological nanoparticle applications. In this webinar we present new insights into these aspects leveraging the unique capabilities of two recently introduced in vivo/ex vivo imaging techniques for spatially resolved monitoring of nanoparticle dose in non-dissected murine lungs.

Conference 2023: Sponsors are welcome. See the current sponsors here: LINK

The following are some of the proposed main topics for the in-person conference 2023 (confirmed details to follow): 

1. "The Amazing journey" tour or an "Inhalation Facility" tour is being planned which is a tour of AstraZeneca (on Friday 5th May 2023 in small groups) and will include speakers from AZ on their Inhalation facilities and recent innovations. This time will also be used to visit the exhibitors and view the posters on display. 

2. Characterisation and Translation of dose for in vitro exposure systems.

3. Inhaled cannabinoids.

4. Foundational data (anatomical and physiological parameters) for respiratory tract across life stages (e.g. 3 months through adulthood).

5. Updates from previous AIT presentations

View the recent recorded AIT webinars, PDF slides and posters at the following links:

2022 completed AIT webinars, PDF slides and submitted posters here

2021 completed AIT webinars, AIT AGM webinar, PDF slides and submitted posters here

2020 completed AIT webinars and PDF slides here

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AIT Conference 2023 - conference registration link below. Please register by selecting  FULL DELEGATE if you need the conference hotel included in your registration fees. 

https://eur.cvent.me/yg8Al

Conference 2023

details

Draft Agenda (subject to change)

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